Did SARS2 or Vaccines Turn the Common Cold Into a Deadly Pathogen?

Make an mRNA therapy against a coronavirus. Trigger antibody dependent enhancement of...the common cold?

Seasonal coronavirus pneumonia after SARS-Cov-2 infection and vaccine: new frenemies?

We report the case of a 43-year-old Paraguayan woman with an acute interstitial pneumonia and respiratory insufficiency by coronavirus OC43 despite past COVID-19 and vaccination. The patient had a history of smoking, hypertension, diabetes, obesity, and liver steatosis. She did not report recurrent respiratory infections. She had a mild COVID-19 infection in October 2020, confirmed by a nasopharyngeal RT-PCR test. She received one dose of Chadox1 Oxford Astra-Zeneca vaccine in March 2021. Asides from residual asthenia, she did not report any other clinical manifestations suggesting long-COVID19. A laboratory test performed between the infection and vaccination showed no significant abnormalities.

She consulted an Emergency Department in June, 2021, referring cough and shortness of breath for five days.

A chest computed tomography was performed, showing ground glass opacities without pleural effusion or significant lymph nodes [image 1], suggestive of progressive COVID-19 (CORADS 5). The initial nasopharyngeal RT-PCR test was negative for SARS-COV2.

. Nasopharyngeal swabs were repeated twice more, and again were negative for SARS-COV2. A rapid-antigen test was performed, which was also negative. SARS-COV2 serology was positive for virus-specific IgG antibodies. Other infections such as HIV, mycoplasma, chlamydia, strongyloides, tuberculosis or legionella were ruled out.

The finally found the culprit:

The test was positive for coronavirus OC43, which was assumed to be the underlying cause of the pneumonia and hypoxemia. After 7 day, she was discharged with complete recovery

Coronavirus OC43 is the common cold. There have been some studies and speculation that suggested OC43 offers some protection from SARS2. At teh start of the paper above, the authors discuss this briefly, as well as studies that show it doesn't.

While current studies have focused on the potential effect of past coronaviruses over SARS-COV2 infection, to our knowledge there has been no investigation on the reverse situation, that is, if SARS-COV2 can have an impact on the incidence or severity of other coronaviruses. The role of antibody-dependent enhancement in human coronaviruses, and for SARS-COV2 in particular, has yet to be established. Further studies and epidemiological surveillance will help to determine if our case is just an oddity or if the current pandemic may yet have other unexpected collateral effects.

Hopefully, this is a one off oddity. The first link above is worrisome though:

There are already cases being reported in the US where the person is vaccinated, presents to the ER with what looks like severe Covid-19 (including the specific markers for Covid such as ground-glass infiltrates in the lungs on X-ray or CT) but repeatedly tests negative.